Tamsulosin Pricing

Tamsulosin 0.2mg

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Tamsulosin 0.4mg

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How does it work

Tamsulosin (brand name: Flomax) is a drug helping overcome troubles associated with urination disorder caused by benign prostatic hyperplasia (BPH). It is selective competitive blocker alfa1a/d-adrenoceptors. It relaxes the smooth muscles of the prostate, bladder neck and prostatic urethra improving urinary flow and reduces the symptoms of irritation and obstruction of the urinary tract associated with benign prostatic hypertrophy. It is suitable for men to treat urination disorders.


The drug is used for the treatment of urination dysfunction associated with benign prostatic hyperplasia and a number of diseases of the prostate and lower urinary tract in men.

Mechanism of action

Tamsulosin selectively and competitively blocks postsynaptic alfa1a/d-adrenoretseptory located in the smooth muscle of the prostate, cervix, bladder detrusor, the prostatic urethra (urethral), as well as in the body of the bladder. This leads to a reduction in smooth muscle of the prostate, bladder neck and prostatic urethra.

It shows positive dynamics in functional symptoms: improving bladder emptying, reduction of residual urine, urinary relief, easing symptoms of obstruction and irritation caused by benign prostatic hypertrophy (BPH) and prostate cancer.

Typically, the therapeutic effect of tamsulosin develops in 2 weeks after initiation of treatment and persists for a long time, which can significantly delay the time need for catheterization or surgery.

Tamsulosin practically does not bind to alfa 1v - adrenoceptors of vascular smooth muscle. Due to the high selectivity of Tamsulosin it does not cause clinically significant decrease in systemic blood pressure in patients with hypertension as well as patients with normal blood pressure.

Dosing and Administration

Dosing and administration

Usually Tamsulosin is taken orally at the single dose 0.4 mg daily after breakfast with plenty of water. It is not recommended to chew capsules or tablets, as this could affect the release rate of the drug.

Due to its high selectivity and lack of hypotensive effect is not necessary to adjust a dose of the drug. For minor to moderate hepatic dysfunction and renal impairment dose adjustment is also not required.



Tamsulosin should not be administered in the following situations:

  • hypersensitivity to tamsulosin

  • individual intolerance of this drug

  • orthostatic hypotension

  • severe liver failure

  • severe hepatic impairment (Child Pugh C classification of CHILD-PUGH involving the simultaneous presence and marked expression of at least four of the following five signs: encephalopathy, ascites, hyperbilirubinemia, hypoalbuminemia, prolonged prothrombin time and indicates a high in the surgical treatment of portal hypertension operative risk)

Tamsulosin is used with caution:

  • severe renal impairment (creatinine clearance less than 10 mL / min)

Side effects

Side effects

Adverse reactions are ranked by frequency as follows: Very common (> 1/10); common (> = 1/100 to <1/10); uncommon (> = 1/1000 to <1/100); rare (> = 1/10000 <1/1000); very rare (> = 1/10000), not known (can not be estimated from available data).

Adverse effects are listed in the following table:

Nervous system:

  • Dizziness (1.3%) - 1/100 < 1/10 (common)
  • Headache - 1/1000 < 1/100 (uncommon)
  • Syncope - 1/10000 < 1/1000 (rare)

Cardiac disorders:

  • Palpitations - 1/1000 < 1/100 (uncommon)

Vascular disorders:

  • Orthostatic hypotension - 1/1000 < 1/100 (uncommon)

Respiratory, thoracic and mediastinal disorders:

  • Rhinitis and nasal congestion - 1/1000 < 1/100 (uncommon)

Gastrointestinal disorders:

  • Constipation, diarrhea, nausea, vomiting - 1/1000 < 1/100 (uncommon)

Skin and subcutaneous tissue disorders:

  • Rash, pruritus, urticaria - 1/1000 < 1/100 (uncommon)
  • Angioedema- 1/10000 < 1/1000 (rare)

Reproductive system and breast disorders:

  • Abnormal ejaculation - 1/1000 < 1/100 (uncommon)
  • Priapism - < 1/10000 (very rare)

General disorders:

  • Asthenia - 1/1000 < 1/100 (uncommon)
During cataract surgery rare cases, known as the syndrome of Intraoperative Floppy Iris (IFIS) has been associated with tamsulosin


Special instructions and precautions:

Before starting treatment with tamsulosin it is necessary to verify the diagnosis. The patient should be examined in order to exclude the presence of other diseases that can cause the same symptoms as benign prostatic hyperplasia. Is necessary to exclude carcinoma (cancer) prostate cancer. Before starting treatment and regularly during therapy with the drug should be performed digital rectal examination and, if required, the definition of prostate specific antigen (PSA).

As with other alpha 1-blockers in some cases there may be a decrease in blood pressure, which can sometimes lead to fainting. Tamsulosin should be used with caution in patients with a predisposition to orthostatic hypotension. At the first signs of orthostatic hypotension (dizziness, weakness) the patient should sit down or lay and leave in this position until the symptoms of this condition will not disappear.

Be wary appoint patients with severe hepatic impairment and decreased creatinine clearance below 10 ml / min. Patients with impaired renal function do not require dose reduction.

This medicine is generally not recommended in patients with a history of micturition syncope and in combination with other alpha1 blockers (see Interactions: alfuzosin, prazosin, terazosin, urapidil).

Drug interaction

Drug interaction

Simultaneous use of cimetidine leads to a slight increase in the concentration of tamsulosin in plasma and furosemide - a decrease of concentration, but it does not require a change in dose of tamsulosin.

Diclofenac and warfarin may increase somewhat elimination rate of tamsulosin.

Other alpha1 blockers (alfuzosin, doxazosin, prazosin, terazosin), acetylcholinesterase inhibitors, alprostadil, anesthetics, diuretics (furosemide, hydrochlorothiazide, spironolactone), levodopa, antidepressants, beta-blockers (propranolol, atenolol, metoprolol, etc.), angiotensin slow calcium channel blockers (nifedipine, amlodipine, etc.), nitrates (nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, etc.), ACE inhibitors (enalapril, captopril etc.), and ethanol can increase the severity of the hypotensive effect of tamsulosin.

Diazepam, propranolol, trichloromethiazide, chlormadinone (Belarus), amitriptyline diclofenac, glibenclamide, simvastatin and warfarin change the free fraction of tamsulosin in human plasma in vitro. In turn Tamsulosin also does not change the free fractions of diazepam, propranolol, trichloromethiazide, chlormadinone.

In vitro studies found no interaction with amitriptyline, salbutamol, glibenclamide and finasteride. Taking tamsulosin concurrently with theophylline interactions were found.

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